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Prescription of Controlled Substances: Benefits and Risks

Controlled substances: These are drugs or medications that possess the potential for being misused and are considered to be substances that have a substantially high risk of resulting in substance use disorder. Opioid analgesics: these are drugs that dull the senses and relieve pain, e.g., morphine.

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URL: Pubmed.ncbi.nlm.nih.gov


Alzheimer's disease drug development pipeline: 2022

(1 days ago) WebWe use the Common Alzheimer's Disease Research Ontology (CADRO) to classify drug targets and mechanisms of action of drugs in the pipeline. Results: As of …

Category:  Health Go Now


Antibody-Drug Conjugates: A Comprehensive Review

(1 days ago) WebAntibody-drug conjugates (ADC) are one of the fastest growing anticancer drugs. This approach comprises a mAb conjugated to the cytotoxic payload via a chemical linker that …

Category:  Cancer Go Now


Drug-Induced Peripheral Neuropathy: A Narrative Review

(1 days ago) WebThe most relevant and up to date research was included. Results: Drug-induced peripheral neuropathy is a common and painful condition caused by many different and frequently …

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Cytochrome P450 Enzymes and Drug Metabolism in Humans

(1 days ago) WebHuman cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, …

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New drug targets for hypertension: A literature review

(1 days ago) WebMoreover, antihypertensive drugs may have adverse effect currently. Hence, new therapeutic targets and treatments are needed to uncovered and exploited to control …

Category:  Health Go Now


Anticancer drugs in wastewater and natural environments: A …

(1 days ago) WebThe consumption of anticancer drugs (also known as chemotherapy drugs or antineoplastic drugs) has augmented over the last decades due to increased cancer incidence. …

Category:  Cancer Go Now


Antisense Oligonucleotides: An Emerging Area in Drug Discovery …

(1 days ago) WebAntisense oligonucleotides (ASOs) bind sequence specifically to the target RNA and modulate protein expression through several different mechanisms. The ASO …

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Commonly prescribed medications and potential false-positive

(1 days ago) WebFalse-positive results for amphetamine and methamphetamine were the most commonly reported. False-positive results for methadone, opioids, phencyclidine, …

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Update on Antiseizure Medications 2022

(1 days ago) WebThe article "Update on Antiseizure Medications 2022" by Dr Abou-Khalil was first published in the February 2016 Epilepsy issue of Continuum: Lifelong Learning in …

Category:  Medications Go Now


Pharmacodynamics

(1 days ago) WebPharmacodynamics is the study of a drug's molecular, biochemical, and physiologic effects or actions. It comes from the Greek words "pharmakon," meaning …

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Multidrug Resistance (MDR): A Widespread Phenomenon in

(1 days ago) WebMultidrug resistance may be also related to antimicrobial drugs, and is known to be one of the most serious global public health threats of this century. Indeed, …

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The effect of non-steroidal anti-inflammatory drugs on faecal flora …

(Just Now) WebThe faecal flora and bacterial antibody levels of 22 patients with active rheumatoid arthritis (RA) were compared with those of 26 patients with osteoarthritis (OA) undergoing …

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Early clinical development of anti-tuberculosis drugs: science

(1 days ago) WebControversy continues over how best to capture "sterilizing activity" of anti-tuberculosis regimens in early clinical development. Selecting surrogate endpoints capable of …

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Hydrophilic or Lipophilic Statins

(1 days ago) WebDrugs can be classified as hydrophilic or lipophilic depending on their ability to dissolve in water or in lipid-containing media. The predominantly lipophilic statins …

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Thrombopoietin Receptor Agonists (TPO-RAs): Drug Class

(1 days ago) WebThe thrombopoietin receptor agonists (TPO-RAs) romiplostim, eltrombopag, avatrombopag, and lusutrombopag carry unique US Food and Drug Administration (US FDA)- and …

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Medication-Induced Hyperlactatemia and Lactic Acidosis: A

(1 days ago) WebThe purposes of this systematic review are to identify published reports of medication-induced lactate level elevations to aid clinicians in diagnosing and comprehending the …

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Immune Checkpoint Inhibitors in Cancer Therapy

(1 days ago) WebUnfortunately, not all patients respond favourably to these drugs, highlighting the role of biomarkers such as Tumour mutation burden (TMB), PDL-1 expression, …

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Targeting p53 for the treatment of cancer

(1 days ago) WebDysfunction of the TP53 (p53) gene occurs in most if not all human malignancies. Two principal mechanisms are responsible for this dysfunction; mutation and downregulation …

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Drug penetration across the blood-brain barrier: an overview

(1 days ago) WebThe brain is one of the most protected organs in the body. There are two key barriers that control the access of endogenous substances and xenobiotics (drugs or toxins) to the …

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Long-term effect of dopaminergic drugs in restless legs. A 2-year

(Just Now) WebThe only side effect was transient nausea reported by two of the 30 patients. The study showed that the relief of symptoms of restless legs syndrome by dopaminergic drugs …

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Drug-induced pancreatitis: an update

(1 days ago) WebAbstract. Background and aims: Many frequently prescribed drugs are suspected to cause acute pancreatitis (AP). The goal of this paper is to bring to light the often occult but real …

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RNA-dependent RNA polymerase (RdRp) inhibitors: The current

(1 days ago) WebThe widespread nature of several viruses is greatly credited to their rapidly altering RNA genomes that enable the infection to persist despite challenges presented …

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